The Laboratory of User Interaction and Software Engineering (LoUISE) was created in 2000 and during the last years has aimed his research activities towards Human- Computer Interaction discipline. Its goals have been always centred in enhancing the quality of interactive systems. With this aim it has stood on other branches of knowledge such as Software Engineering, Artificial Intelligence or Design of Control Systems for the development of cyber-physical systems. Nowadays the group consist of ten researchers belonging to the University of Castilla-La Mancha (UCLM). Throughout the trajectory of the group, the laboratory has included a high number of researchers that now are working both in Spain and abroad in different educational and research institutions and companies.